Humoral responses and immune protection in mice immunized with irradiated T. gondii tachyzoites and challenged with three genetically distinct strains of T. gondii
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چکیده
منابع مشابه
Immunogenicity of Gamma-Irradiated Toxoplasma gondii Tachyzoites in Mice
The Immunogenicity of γ-irradiated tachyzoites of a highly virulent strain of Toxoplasma gondii (RH strain) was investigated. Immunized mice survived challenge infection and displayed increased interferon gamma (INF-γ ) production. On the other hand, nonimmunized controls died after 10 days and displayed a significantly decreased lymphoproliferative response to Concanavalin A (Con A). No tachyz...
متن کاملImmune Responses of Mice Intraduodenally Infected with Toxoplasma gondii KI-1 Tachyzoites
Toxoplasma gondii Korean isolate (KI-1) tachyzoites were inoculated intraduodenally to BALB/c mice using a silicon tube, and the course of infection and immune responses of mice were studied. Whereas control mice, that were infected intraperitoneally, died within day 7 post-infection (PI), the intraduodenally infected mice survived until day 9 PI (infection with 1 × 10(5) tachyzoites) or day 11...
متن کاملimmunogenicity of gamma-irradiated toxoplasma gondii tachyzoites in mice
the immunogenicity of γ-irradiated tachyzoites of a highly virulent strain of toxoplasma gondii (rh strain) was investigated. immunized mice survived challenge infection and displayed increased interferon gamma (inf-γ ) production. on the other hand, nonimmunized controls died after 10 days and displayed a significantly decreased lymphoproliferative response to concanavalin a (con a). no tachyz...
متن کاملImmunization with a DNA plasmid encoding the SAG1 (P30) protein of Toxoplasma gondii is immunogenic and protective in rodents.
Immunization with DNA can induce humoral and cell-mediated immune responses, both of which are important in conferring immunity to Toxoplasma gondii. The efficacy of genetic vaccination with a cDNA encoding the T. gondii SAG1 (P30) surface antigen was evaluated. Sera of immunized mice showed recognition of T. gondii tachyzoites by immunofluorescence and exhibited high titers of antibody to SAG1...
متن کاملStudy of resistance to Toxoplasmosis using Tachizoites surface antigens of Toxoplasma gondii in vivo
Taoxoplasma gondii is an important food-borne parasite transmitted primarily from animals to humans through meat consumption, mainly pork and lamb, as well as through oocysts shed by cats. Infection in humans can cause severe fetal malformations, ocular complications or encephalitis. Toxoplasmosis infection during pregnancy, especially in sheep, often results in abortion, representing considera...
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ژورنال
عنوان ژورنال: Immunology Letters
سال: 2011
ISSN: 0165-2478
DOI: 10.1016/j.imlet.2011.04.007